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Given these distinct pathophysiological dynamics and therapeutic priorities, stroke will not be discussed further in this review, which focuses instead on chronic neurological diseases characterized by progressive neuronal loss, complex molecular interactions, and the need for sustained neuroprotective strategies

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Am J Physiol Cell Physiol 281:C1495C1503 Lewerenz J, Maher P, Methner A (2011) Regulation of xCT expression and system x c function in neuronal cells