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In the SURPASS clinical trial program, tirzepatide reduced HbA1c by 2.0-2.4% depending on dose, bringing the majority of participants to target levels below 7.0%
doi:10.1016/j.gofs.2023.06.001
For those interested in cutting-edge telomere biology, epitalon is the more targeted option but carries greater uncertainty
The underlying mechanism may be related to a key modulator of neutrophil maturation, granulocyte-macrophage colony-stimulating factor (GM-CSF), which was observed to be higher in young adult females than males, followed by diminishing after menopause (53)