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Phase 2 (Jastreboff et al., NEJM 2023) reported 24.2% weight loss at 48 weeks at 12 mg

By session six, the change is durable enough that a friend who has not seen you in three months comments

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The AAV9 serotype, however, has been found to have the ability to efficiently cross the BBB when intravenously delivered to neonatal and adult mice [156]