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Similarly, the amide bonds between SA and amino groups in MSNs-ss-SA can be cleaved by amidase, leading to the release of SA [46]

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It has a smaller molecular size, which makes it easier for it to penetrate the dermis and have a more pronounced effect at the cellular level

Gudzune et al ., 2025 "Association between weight reduction achieved with tirzepatide and quality of life in adults with obesity: Results from the SURMOUNT-1 study"