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Richie, John P Jr et al

FXR activation rescues lipid peroxidation, intracellular ROS, and Fe 2+ accumulation, inhibits ferroptosis, and alleviates nephrotoxicity (Tang et al., 2023)

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Medically reviewed by: Jayden Lee, PharmD, EMBA Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes

Its decline with aging represents a key mechanistic link between circadian disruption and downstream metabolic and oxidative consequences, as discussed in the following section