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A study at the University of Adelaide looking at ways to trigger release of the gut hormone GLP-1 - the hormone upon which weight-loss drugs are based - previously found that giving a bile acid enema to healthy volunteers triggered release of GLP-1, but had the unintended consequence of causing diarrhea

Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials

20 September 2013

10.1248/bpb.29.291 106 ZheL.ZhenkunZ.YuepingR.YingyingW.JiaruiF.YueH.et al (2021)

The Nrf2 pathway responds to ROS by activating the transcription of phase II detoxification enzymes