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Similar content being viewed by others Introduction Glutathione (GSH) is the most abundant non-protein thiol in eukaryotic cells

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While the majority of EC cases are low-grade, early-stage endometrioid EC with favorable prognosis, approximately 1020% fall into the high-risk category, characterized by grade 3 endometrioid tumors (G3EEC), serous ECs (SEC), clear-cell ECs (CCEC), and dedifferentiated carcinosarcomas, all of which exhibit significantly poorer outcomes [3, 4]

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Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts