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Inhibitory effect of tumor cell-derived lactic acid on human T cells

Uniquely, it had a time period at the end of the study where study medication was discontinued for 12 weeks, then reassessed to see if the treatment effects persisted

Following the injection, in vivo imaging was conducted using an IVIS Spectrum (PerkinElmer) at various time points: 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, and 48 h post-injection, utilizing an excitation wavelength of 780 nm and a fluorescence emission wavelength of 840 nm

The disease burden was similarly calculated as the sum of the histopathological changes in a mouse and severity of neoplastic and renal lesions was assessed using an established grading system

The spleen subsequently destroys these damaged cells, causing acute haemolytic anaemia