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When the CLO dose was reduced to 500 mg/day, the confusion disappeared within 1 week and the plasma CLO concentration returned to the pre-smoking cessation level (20)

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Clotting disorders and heart defects are some of the causes of ischemic strokes, and the causes of hemorrhagic strokes could be high blood pressure, brain tumors, and brain aneurysms

[38] These trends demonstrate the complex and evolving role of tobacco in the 19th century, setting the stage for further developments in the 20th century and beyond

Nicotine seems to alternate between acting as a stimulant and a depressant