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This helps protect you from other health issues because inflammation is linked to things like cancer, heart disease, diabetes, and Alzheimers disease

In normal endometrial tissue, oestrogen may inhibit autophagy in the endometrium by inhibiting the hypoxia-inducible factor-1/ROS/AMP-activated protein kinase signalling pathway and further activating mammalian target of rapamycin complex (mTOR) signalling during nonmenstrual periods [100]

The darkening of your skin is called hyperpigmentation, which occurs due to prolonged exposure to UV rays and high levels of melanin

Sep 2008;24(9):806-814