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Native IGF-1 exists predominantly bound to IGF-binding proteins (IGFBPs) in circulation, which sequester the growth factor and limit its bioavailability to target tissues

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I was a 'heavy drinker' throughout my twenties which wasn't helped by a boozy City of London Insurance career

10.1016/j.expneurol.2013.12.020 4 AleA.BrunaJ.HerrandoM.NavarroX.UdinaE

[PMC free article: PMC4124995] [PubMed: 23984999] (Commentary on use of biomarkers to predict acetaminophen hepatotoxicity and recent study by Anoine [2013], stressing the need for a very high negative predictive value for any test result to guide management [withholding acetylcysteine therapy])