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The net effect in cell culture is increased deposition of structurally mature extracellular matrix

MicroRNA 146a is believed to interact with intracellular mediators such as interleukin 1 receptor-associated kinase 1 and mammal-affiliated tumor necrosis factor receptor-associated factor 6, both of which are involved in cytokine-related signal transduction

They were mainly gastrointestinal, and only one patient in that group discontinued due to side effects

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