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Lens-enriched lanosterol is the first sterol intermediate in the cholesterol biosynthetic pathway, which is mediated by lanosterol synthase (LSS) (149)

Comprehensive analysis of lung macrophages and dendritic cells in two murine models of allergic airway inflammation reveals model- and subset-specific accumulation and phenotypic alterations

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In general, but not necessarily, the homozygous variant, often the minor allele, may confer to the affected individual a higher susceptibility in comparison with the homozygous wild-type and heterozygous condition, particularly in the occupational context wherein the exposure to chemical and physical agents may worsen the disorder