Vamifeport (VIT-2763), as a novel oral FPN inhibitor, induces dose-dependent internalization and ubiquitination of FPN in cells, improving iron homeostasis in mouse models of -thalassemia
Examples include OATD-02, a recently developed ARG1/2 dual inhibitor with 15 nM affinity ( 50 values of 86 nM and 296 nM for ARG1 and ARG2, respectively (Naing et al., 2024
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PubMed, Hao, Liuyi, et al
Glutathione can protect important cellular components from damage caused by reactive oxygen species, such as free radicals, peroxides, lipid peroxides, and heavy metals