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doi: 10.1007/s00438-012-0723-7 24

Although the endocrine/paracrine effects of bone on muscle or vice versa cannot be firmly established at present, these findings indicate that muscle and bone share similar IGF-1 responsive gene networks, strengthening the case for the role of IGF signaling in coordinated maintenance of bone and muscle

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The fact that albumin is a driver of pathogenicity in vivo still requires confirmation