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Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation

TB-500: Modulates actin polymerization, enhances cellular motility, supports angiogenesis, and reduces inflammation through the regulation of cytokine production and promotion of anti-inflammatory macrophage polarization

Zhang, S., Lachance, B