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When confronted with harmful substances such as toxins or byproducts of oxidative stress in the periphery or brain tissue, the vascular system flexibly initiates defensive mechanisms to mitigate potential harm, demonstrating an adaptive response that protects the BBBs protective function

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Headache 60(1):200216 Demartini C, Francavilla M, Zanaboni AM et al (2023) Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings

According to the intersection point, we further conducted the Landmark analysis to assess the mortality risk occurring before and after 9 years of follow-up across tertiles of serum B12

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