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Complexation with 2-hydroxypropyl--cyclodextrin also significantly enhanced AS-IV bioavailability in rats ( Additionally, derivatives of AS-IV, such as LS-102, have shown enhanced pharmacological activity at comparable concentrations (Wan et al., 2023)

77 Increased excitatory neurotransmission, 78 enhanced non-auditory projections, 79 and changes in GABAergic transmission contribute to the excitatoryinhibitory imbalance

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