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Larazotide's barrier-restoration effect addresses the bidirectional gut-oral microbiome relationship strengthening the mucosal defense layer that systemic inflammation and periodontal disease progressively erode

Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

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