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indeed, Th1 cells have pro-inflammatory effects (a CD4 + T cell subsets) as do CD8 + T cells, while Th2 cells and regulatory T cells (Tregs) have anti-inflammatory effects (152)
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Under therapeutic stress, subpopulations enhance mitochondrial respiration, FAO, and TCA cycle activity, promoting redox balance and bioenergetic resilience that underpin chemoresistance and metastatic potential [108]
The LAT transmembrane domain and palmitoylation at Cys26 are required for its stability and lipid raft localization ( Figure 5 )
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