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FIGURE 1 Glutathione Metabolism Is Related to Ferroptosis System Xc is a Na + -dependent cysteine-glutamate antiporter located in the membrane that is composed of SLC3A2 and SLC7A11 (xCT) and responsible for the exchange of intracellular glutamate for extracellular cystine at a 1:1 ratio ( via the GSH synthesis process ( de novo GSH synthesis ( , which is not regulated by ATP, is activated by high concentrations of intracellular glutamate

They are used to develop new drugs and therapies, as they can target specific receptors and modulate biological pathways [4]

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