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Of the four studies that assessed changes in Glx, three saw a decrease in the GABA/Glx ratio, a finding in line with our hypotheses described in section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS and above

Importantly, results are typically visible after a single session, with cumulative benefits observed over successive treatments due to progressive tissue remodeling

A Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation

Caggiano C, Pieraccioli M, Pitolli C, Babini G, Zheng D, Tian B, et al

Similarly, damage to blood vessels supplying the brain can lead to stroke