This suggests that pathology in the pulmonary artery wall, particularly when it affects the intimal layer, may play a key role in determining the loss of vascular response to hypoxia that contributes to V A /Q mismatching
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J.MathiasS
Funding Open Access funding enabled and organized by CAUL and its Member Institutions Murdoch Childrens Research Institute,James Cook University,National University of Singapore Ethics declarations Conflicts of interest The authors declare no competing interests
Interestingly, a recent clinical trial in climacteric women working fixed shifts found that low-dose exogenous melatonin administered for three months did not significantly alter dietary intake or body composition, although postmenopausal participants showed modest reductions in fat mass, suggesting that physiological melatonin doses may have limited impact on metabolic outcomes in NS workers 190
