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According to FDA guidance, patients should use a non-oral contraceptive method or backup contraception for 4 weeks after starting Zepbound and after each dose increase, as delayed gastric emptying may reduce oral contraceptive absorption and effectiveness

It was tested on healthy volunteers and on a small cohort of patients with Crohns disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Lozic M., Stambolija V., Krezic I., Dugandzic A., Zivanovic-Posilovic G., Gojkovic S., Kovacevic J., Vrdoljak L., Mirkovic I., Kokot A., et al

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The pancreatic beta cells need time to calibrate their insulin response to the new signaling pattern