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If the same active substance shown in the figure above is given via another route, such as a tablet given orally (by mouth), the bioavailability is lower than 100% (see figure below, Oral bioavailability)

The application of tretinoin (ATRA) in melasma lesions in concentration ranges of 0.05%0.1% could effectively decrease skin pigmentation

However, male fertility parameters showed notable reductions, including decreased weight of the testis, epididymis, and seminal vesicle, as well as reduced sperm count and motility at doses of 300 and 600 mg/kg (700)

Function of nuclear factor kappa B (NF-kB) in human diseases-a review

Longevity and healthspan 3:6