Mice were randomized into seven groups: a saline control group (CON), a saline control treated with GHRP-6 (CON + GHRP-6), a doxorubicin-only group (DOX), a doxorubicin group treated with GHRP-6 (DOX + GHRP-6), a doxorubicin group treated with GHRP-6 and the GHSR antagonist YIL781 (DOX + GHRP-6 + YIL781), a doxorubicin group treated with GHRP-6 and the CCR5 antagonist TAK-779 (DOX + GHRP-6 + TAK-779), and finally a doxorubicin group treated with GHRP-6 alongside the CXCR4 antagonist AMD3100 (DOX + GHRP-6 + AMD3100)
High-dose protocols (1.52mg daily) push toward the upper threshold where copper ion accumulation becomes a concern
PUFA-O-OH then reacts with Fe 2+ to generate ROS
[Abstract]2022 Nov 11;12(50):32328-32337
J Gastroenterol Hepatol 7:711 Barbaro G, Di Lorenzo G, Soldini M, Parrotto S, Bellomo G, Belloni G et al (1996) Hepatic glutathione deficiency in chronic hepatitis C: quantitative evaluation in patients who are HIV positive and HIV negative and correlations with plasmatic and lymphocytic concentrations and with the activity of the liver disease
