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Lack of SMARCA4 inhibits expression of the aldehyde dehydrogenase ALDH16A1 that binds to the Trx1 active site and inhibits its function but also promotes lysosomal degradation of the redoxin [95]

doi:10.1186/s12917-021-02929-3

Hansen, L., Deacon, C

2016, The American College of Clinical Pharmacology Posted May 30, 2019

Patients switching between forms should adjust doses accordingly to avoid unintentional dose escalation and the attendant hypoglycemia or thyroid effects at higher exposures