Both compounds share the same regulatory timeline: moved to Category 2 in 2023, removed from Category 2 in April 2026, and scheduled for PCAC review on July 23, 2026
A 140 is less so, with an increasing ratio of A 142 to A 140 leading to increased oligomerization and toxicity, possibly due to the inhibitory effect of the A 140 isoform (Qiu et al., 2015
Anesthesiology 93(6):15391541 Sikiric P, Gyires K, Seiwerth S et al (1993) The effect of pentadecapeptide BPC 157 on inflmammatory, non-inflammatory, direct and indirect pain and capsaicin neortoxicity
Contamination is the first
Copper is only required in trace amounts by the body, and too much copper buildup could theoretically cause nausea, abdominal pain, tiredness, liver damage, and neurological effects