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Synthetic peptides are engineered to improve bioavailability, target selectivity, and half-life, often surpassing the pharmacokinetic limitations of natural peptides. Vlieghe et al., Drug Discovery Today Do Natural and Synthetic Peptides Have Different Clearance Times

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And more intriguinglywhy does a peptide originally found in human gastric juice have such a profound effect on the entire body

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Shelp BJ, Bozzo GG, Trobacher CP, Zarei A, Deyman KL, Brikis CJ (2012) Hypothesis/review: contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress