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First, oxidative stress can induce the activation of mitochondrial pathways

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Suitable candidates often include middle-aged adults, especially women, and individuals who are overweight or engage in prolonged standing or high-impact activities

This initiates caspase activation and myonuclear apoptosis ( In addition, mitochondria form functional contact sites with the sarcoplasmic reticulum (SR) at mitochondria-associated membranes (MAMs), where Ca 2+ is transferred through the IP 3 R-Grp75-VDAC1 complex