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As a general clinical principle: Retest HbA1c no sooner than three months after commencing B12 replacement therapy, and ideally once haematological recovery has been confirmed Confirm haematological recovery normalisation of MCV and haemoglobin before interpreting the repeat HbA1c as reliable Use interim glucose monitoring such as fasting plasma glucose, OGTT, or self-monitored blood glucose (SMBG) to assess glycaemic control during the treatment period

Certain health conditions that affect the gut, like Crohns or celiac disease, can also make absorption a major challenge

The participant has the opportunity to postpone the visit for 3 days, for example, in case of illness or travelling and may miss a maximum of two injections in order to follow per-protocol analysis

PMC 3875920