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Furthermore, we observed that ACTL6A suppression sensitized GC cells to H 2 O 2 , erastin, and buthionine sulfoximine (BSO), which are ferroptosis inducers, but not to compounds (e.g., etoposide and doxorubicin) that inhibit cell growth through other mechanisms (Fig

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These include the use of Smoothened (Smo) agonists to activate Shh signaling, as well as small-molecule modulators of intraflagellar transport (IFT) proteins to restore ciliary trafficking and structural integrity [263268]