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The HLA- B*5701 allele is also associated with the thrombin inhibitor ximelagatran (OR, 45) and lapatinib-related DILI

doi: 10.1016/j.ygcen.2017.09.027 75 LessiMGiordanoMMomiglianoRichiardiPParacchiniRBonaGPetriAet al

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7 However, recently several studies reported a protective role of ROS in immune-mediated inflammatory disease, because an imbalance between ROS generation and scavenging may contribute to abnormal T-cell responses

These concerns are commonly associated with increased melanin production the natural pigment responsible for skin colour as well as slower cellular turnover, which can lead to a dull appearance