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Given that an increase, but not a decrease, in the Kyn/Trp ratio is expected to be associated with inflammation, and that we observe a one-directional trend towards increased values among the asymptomatic V30M carriers compared to controls (Table 2

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Clinical investigations have shown that melatonin concentrations in the CSF of patients with AD are several-fold lower than those in age-matched control subjects without AD [75, 229]

H.GrevesseT.et al (2018)