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This protective effect extended to other stressors, as glutathione amino acid precursors also shielded cells from blue light-induced ROS production and pollutant-induced ATP depletion, demonstrating a broad-spectrum protective action

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Furthermore, owing to the potential of multi-organ involvement, multidisciplinary care is often required [109,110,111,112]

Neurodegenerative diseases typically disrupt energy metabolism in the brain, and EVs carrying microRNAs (miRNAs) are broadly engaged in this process

Consequently, mitophagy serves to protect neurons from damage in HD, and a deficiency in this process contributes to further malignant deterioration of HD pathology