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Maternal and Fetal Health : During pregnancy, vitamin B12 is crucial for fetal development

Quality varies significantly between suppliers, making it essential to source from reputable vendors who provide third-party testing and certificates of analysis

About 15% of patients are non-responders, often due to concurrent nutrient deficiencies (like magnesium or folate) that require additional supplementation for full therapeutic effect

Concomitant medicines : Clinicians should review all concurrent medications, particularly insulin or sulfonylureas, given the potential for hypoglycaemia with incretin-based agents

The mechanisms are complementary, not competitive