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6.3 Limitations of novel delivery systems Although recent studies have reported substantial improvements in the delivery efficiency and therapeutic performance of flavonoids using advanced delivery systems, including enhanced stability, bioavailability, and targeting efficiency ( For topical administration routes, including dermal and ocular delivery, hydrogels and nanogels are often limited by suboptimal skin permeability, poor adhesiveness, and challenges in large-scale manufacturing (Grillo et al., 2019

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CVB-induced immune responses may also contribute to islet autoimmunity