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Emerging evidence indicates that contraction-induced radical production occurs primarily in the cytosol of the muscle and the magnitude of exercise-induced radical production is influenced by several factors, including environmental conditions and the intensity and duration of exercise (Powers et al., 2011

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Secondarily, the thiolate oxidizability in most biomolecules is modulated by the adjacent basic groups, since protonation of any such group exerts an electron-withdrawing effect on the thiolate

As with any injection procedure, there are risks of serious complications, but the incidence is rare

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