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These findings suggest that UroA may have broad applications for improving energy metabolism, especially in populations experiencing age-related declines in mitochondrial efficiency (Reference Andreux, Blanco-Bose and Ryu14)

Importantly, inefficient elimination of mitochondria in red blood cell (RBC) precursors of sickle-cell disease patients results in mitochondrial retention in mature erythrocytes with consequent increased ROS generation and accelerated hemolysis [60, 61]

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Epidermal barrier function: clinical implications and therapeutic