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Maternal nicotine consumption not only dysregulates energy metabolism, including hormonal imbalance (leptin, insulin), even it increases the risk of metabolic syndromes such as obesity and hyperleptinemia and larger adipocytes in the offspring during adulthood [236, 237]

reported that the PK and abuse liability parameters of ENDS systems do not vary across flavors and at different nicotine concentrations 41,47

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