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Strengths and Limitations The strengths of this meta-analysis include the large pooled sample size (24,000 participants, from multinational countries like USA, UK, South Korea, Canada, and Colombia), the integration of multiple biomarker types (nicotine metabolites, TSNAs, and cytokines), and the application of GRADE methodology to assess the certainty of evidence

Specifically, the price index in urban areas increased by 0.2% while that in rural areas increased by 0.1%

The company employed more than 21,500 people in Europe as of 2023 and had 20 manufacturing sites there

This means that retailers are not allowed to have tobacco products openly displayed for customers to access without assistance from a store employee