Conventional pharmacological therapy options include aminosalicylates, corticosteroids and thiopurines
That said, always check with your provider before adding new therapies to your regimen to avoid unnecessary overlap or interactions
For those managing a confirmed deficiency rather than simply maintaining levels, the treatment approach shifts significantly
5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function
We will compare the mean Bayley-III scores (scores on the cognitive, language and motor subscale scores, with the language scale analysed both separately for receptive and expressive language and as a composite measure, and the motor scale analysed both separately for fine and gross motor development and as a composite measure) between the vitamin B 12 group and the placebo group
