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In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]

The global resolutions were calculated according to the gold standard Fourier shell correlation (GSFSC) criterion of 0.143

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The sensitivity of R 4 parameters ( k p4 ) with respect to model OCR output is in good accordance with the AIC/BIC analysis, confirming the need for the R 4 reaction, which is present in both the triad and the comproportionation models, but not in the reduced model