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Since imine bonds hydrolyze under acidic conditions, the gatekeeper molecules such as PEG, polyglycerol, peptide, and carbohydrate could be severed from the surface at low pH thus opening the pores and releasing the loaded guest molecules 131,132,133

For example, in 8.3% of the 60 ASD patients, biochemical markers of failed aerobic respiration were found [69]

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HAV does not cause chronic infection and should not be in the differential diagnosis of chronic hepatitis

demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)