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Using the data from 19 case-controlled studies, 5 cross-sectional studies, and 3 prospective studies published before 1995, the meta-analysis of Boushey and colleagues (Boushey et al, 1995) relating basal hyperhomocysteinemia to atherosclerotic vascular disease indicates that, above 10 mol/L, a 5 mol/L increment in circulating homocysteine is associated with a significant increase in the risk of coronary artery disease (60% in men and 80% in women)