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Serpina3k lactylation protects from cardiac ischemia reperfusion injury

Intriguingly, despite robust inflammatory activation, they reported no changes in the expression of canonical tight junction proteins (e.g., Cldn5), adherens junction molecules (e.g., Cdh1), or components of the basal lamina across both early and late phases of the disease model

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Results vary depending on health and lifestyle, but effects often last up to a week or more