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It may be relevant when remodeling occurs under metabolic strain, including GLP-1 use, caloric deficit, chronic fatigue, or age-related NAD+ decline

Clin Chim Acta 333:1939 Penninckx M (2000) A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses

Sudden onset with fever, loss of bladder control, or progressive weakness needs immediate evaluation