Ethno-medicinal and bio-cultural importance of aloes from south and east of the great rift valley floristic regions of Ethiopia
Nestin structure and predicted function in cellular cytoskeletal organisation
To investigate the molecular mechanisms underlying curcumin's antimetastatic activity, one study employed qPCR and Western blotting to detect changes in gene and protein expression ( in vitro and in vivo models ( Another study also investigated the role of the p53/miR-34 axis in mediating the anticancer effects of curcumin in CRC ( In vivo , intravenous injection of CRC cells into non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice showed that curcumin prevented lung metastasis formation in a miR-34a-dependent manner, suggesting curcumin induces mesenchymal-to-epithelial transition (MET) ( 3.1.5 Reversal of chemoresistance In another study, the effects of curcuminoids on CRC were investigated using two human colon cancer cell lines, human tumor 29 (HT29) and SW480, alongside normal CCD-18Coa human colon fibroblast cell line derived from normal colon tissue ( In another study using HCT116 and SW620 colon cancer cell lines, researchers investigated the molecular mechanism underlying curcumin's anticancer activity, with a particular focus on the miR-134-5p/CDCA3/CDK1 signaling pathway ( in vivo , SW620 cells were injected into mice to establish xenograft tumors, allowing for evaluation of curcumin's effects on tumor progression ( In vivo experiments supported these findings, as curcumin treatment significantly reduced tumor growth in mice, accompanied by increased miR-134-5p expression and reduced CDCA3 and CDK1 levels
References Gibellini L, Pinti M, Nasi M, et al
What is the purity standard for cosmetic GHK-Cu
