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Results VRK2-deficient PC cells are vulnerable to GSH inhibition To investigate the impact of VRK2 on metabolic reprogramming, we treated VRK2-wild-type (VRK2-WT) and VRK2-knockout (VRK2-KO) CFPAC-1 cell lines with 281 metabolism compounds (Supplementary Table1)

SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b(+) cells

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Cell death is an essential hallmark of life, and ferroptosis is a specific form of cell death distinct from necrosis, apoptosis, or autophagy that is linked to certain physiological and pathological processes