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The most often and potent ones attracted are the insulin receptor substrates 1/2 (IRS1/2)although there are 6 found to date- (not to forget that Shc proteins, p60dok, Cbl, APS, and Gab-1 are also recruited to activated IRs)

This shift in scientific interest has led to exploration of natural sources as potential alternatives

I.IdaT.OkamotoT.et al (2010)

10.1002/glia.20919 395 ZhouQ.ZhuL.QiuW.LiuY.YangF.ChenW.et al

When cultured murine skeletal muscle cells were atrophied by the pro-inflammatory cytokine TNF-, not only did trimetazidine significantly reverse the reduction in myotube size, it also increased myosin heavy chain expression and induced hypertrophy [160]